Northwestern University Feinberg School of Medicine

Department of Physiology

Publications

2017

Surmeier DJ, Obeso JA, Halliday GM (2017) Selective neuronal vulnerability in Parkinson disease. Nat Rev Neurosci 18(2), 101-113.

2016

Kita T, Shigematsu N, Kita H (2016) Intralaminar and tectal projections to the subthalamus in the rat. Eur J Neurosci 44(11), 2899-2908.

Cui Q, Pitt JE, Pamukcu A, Poulin JF, Mabrouk OS, Fiske MP, Fan IB, Augustine EC, Young KA, Kennedy RT, Awatramani R, Chan CS (2016) Blunted mGluR Activation Disinhibits Striatopallidal Transmission in Parkinsonian Mice. Cell Rep 17(9), 2431-2444.

Surmeier DJ, Schumacker PT, Guzman JD, Ilijic E, Yang B, Zampese E (2016) Calcium and Parkinson's disease. Biochem Biophys Res Commun.

Glajch KE, Kelver DA, Hegeman DJ, Cui Q, Xenias HS, Augustine EC, Hernández VM, Verma N, Huang TY, Luo M, Justice NJ, Chan CS (2016) Npas1+ Pallidal Neurons Target Striatal Projection Neurons. J Neurosci 36(20), 5472-88.

Hegeman DJ, Hong ES, Hernández VM, Chan CS (2016) The external globus pallidus: progress and perspectives. Eur J Neurosci 43(10), 1239-65.

2015

Cooper G, Lasser-Katz E, Simchovitz A, Sharon R, Soreq H, Surmeier DJ, Goldberg JA (2015) Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus. J Neurophysiol 114(3), 1513-20.

Hernández VM, Hegeman DJ, Cui Q, Kelver DA, Fiske MP, Glajch KE, Pitt JE, Huang TY, Justice NJ, Chan CS (2015) Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus. J Neurosci 35(34), 11830-47.

Chu HY, Atherton JF, Wokosin D, Surmeier DJ, Bevan MD (2015) Heterosynaptic regulation of external globus pallidus inputs to the subthalamic nucleus by the motor cortex. Neuron 85(2), 364-76.

2014

Wilson CJ (2014) Oscillators and Oscillations in the Basal Ganglia. Neuroscientist.

Fieblinger T, Graves SM, Sebel LE, Alcacer C, Plotkin JL, Gertler TS, Chan CS, Heiman M, Greengard P, Cenci MA, Surmeier DJ (2014) Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia. Nat Commun 5, 5316.

Surmeier DJ, Graves SM, Shen W (2014) Dopaminergic modulation of striatal networks in health and Parkinson's disease. Curr Opin Neurobiol 29, 109-17.

Gittis AH1, Berke JD2, Bevan MD3, Chan CS3, Mallet N4, Morrow MM5, Schmidt R6 (2014) New roles for the external globus pallidus in basal ganglia circuits and behavior. J Neurosci 34(46), 15178-83.

Sanchez-Padilla J, Guzman JN, Ilijic E, Kondapalli J, Galtieri DJ, Yang B, Schieber S, Oertel W, Wokosin D, Schumacker PT, Surmeier DJ (2014) Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. Nat Neurosci 17(6), 832-40.

Heiman M, Heilbut A, Francardo V, Kulicke R, Fenster RJ, Kolaczyk ED, Mesirov JP, Surmeier DJ, Cenci MA, Greengard P (2014) Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia. Proc Natl Acad Sci USA 111(12), 4578-83.

2013

Wilson CJ (2013) Active decorrelation in the basal ganglia. Neuroscience 250, 467-82.

Dryanovski DI, Guzman JN, Xie Z, Galteri DJ, Volpicelli-Daley LA, Lee VM, Miller RJ, Schumacker PT, Surmeier DJ (2013) Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons. J Neurosci 33(24), 10154-64.

Kang S, Cooper G, Dunne SF, Luan CH, Surmeier DJ, Silverman RB (2013) Structure-activity relationship of N,N'-disubstituted pyrimidinetriones as Ca(V)1.3 calcium channel-selective antagonists for Parkinson's disease. J Med Chem 56(11), 4786-97.

Sulzer D, Surmeier DJ (2013) Neuronal vulnerability, pathogenesis, and Parkinson's disease. Mov Disord 28(6), 715-24.

Surmeier DJ, Schumacker PT (2013) Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease. J Biol Chem 288(15), 10736-41.

Surmeier DJ, Sulzer D (2013) The pathology roadmap in Parkinson disease. Prion 7(1), 85-91.

2012

Kang S, Cooper G, Dunne SF, Dusel B, Luan CH, Surmeier DJ, Silverman RB (2012) CaV1.3-selective L-type calcium channel antagonists as potential new therapeutics for Parkinson's disease. Nat Commun 3, 1146.

Fan KY, Baufreton J, Surmeier DJ, Chan CS, Bevan MD (2012) Proliferation of external globus pallidus-subthalamic nucleus synapses following degeneration of midbrain dopamine neurons. J Neurosci 32(40), 13718-28.

Goldberg J.A., Guzman J.N., Estep C.M., Ilijic E, Kondapalli J., Sanchez-Padilla J., Surmeier D. J. (2012) Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson’s disease Nat Neurosci 15(10), 1414-21.

Fan KY, Baufreton J, Surmeier DJ, Chan CS, Bevan MD (2012) Proliferation of external globus pallidus-subthalamic nucleus synapses following degeneration of midbrain dopamine neurons. J Neurosci 32(40), 13718–13728.

Farries, MA and Wilson, CJ (2012) Phase response curves of subthalamic neurons measured with synaptic input and current injection. J. Neurophysiol 108(7), 1822-37.

Farries, MA and Wilson, CJ (2012) Biophysical basis of the phase response curve of subthalamic neurons. J. Neurophysiol 108(7), 1838-55.

Goldberg JH, Farries MA, Fee MS.  (2012) Integration of cortical and pallidal inputs in the basal ganglia-recipient thalamus of singing birds. J Neurophysiol 108(5), 1403-29

Ko D, Wilson CJ, Lobb CJ, Paladine CA (2012) Detection of bursts and pauses in spike trains.  J. Neurosci. Methods 211(1), 145-58.

2011

Atherton JF, Kitano K, Baufreton J, Fan K, Wokosin D, Tkatch T, Shigemoto R, Surmeier DJ, Bevan MD (2010) Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus. J Neurosci 30: 16025-16040.

Chan, C.S., Glajch, K.E., Gertler, T.S., Guzman, J.N., Mercer, J.N., Lewis, A.S., Goldberg, A.B., Tkatch, T., Shigemoto, R., Fleming, S.M., et al. (2011). HCN channelopathy in external globus pallidus neurons in models of Parkinson’s disease. Nat Neurosci 14, 85-92.

Ilijic, E., Guzman, J.N., Surmeier, D.J. (2011) The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson’s disease. Neurobiology of Disease Neurobiol Dis 43(2), 364-71.

Kita, T. & Kita, H. (2011) Cholinergic and non-cholinergic mesopontine tegmental neurons projecting to the subthalamic nucleus in the rat. Eur J Neurosci. 33, 433-443.

Nishibayashi, H., Ogura, M., Kakishita, K., Tanaka, S., Tachibana, Y., Nambu, A., Kita, H. & Itakura, T. (2011) Cortically evoked responses of human pallidal neurons recorded during stereotactic neurosurgery. Mov Disord 26(3):469-76.

Kita H, Kita T (2011) Cortical stimulation evokes abnormal responses in the dopamine-depleted rat Basal Ganglia. J Neurosci 31:10311-10322.

Kita T, Kita H (2011) Cholinergic and non-cholinergic mesopontine tegmental neurons projecting to the subthalamic nucleus in the rat. Eur J Neurosci 33:433-443.

Chan CS, Glajch KE, Gertler TS, Guzman JN, Mercer JN, Lewis AS, Goldberg AB, Tkatch T, Shigemoto R, Fleming SM, Chetkovich DM, Osten P, Kita H, Surmeier DJ (2011) HCN channelopathy in external globus pallidus neurons in models of Parkinson’s disease. Nat Neurosci 14:85-92.

Kita H, Kita T (2011) Role of Striatum in the Pause and Burst Generation in the Globus Pallidus of 6-OHDA-Treated Rats. Front Syst Neurosci 5:42.

Nishibayashi H, Ogura M, Kakishita K, Tanaka S, Tachibana Y, Nambu A, Kita H, Itakura T (2011) Cortically evoked responses of human pallidal neurons recorded during stereotactic neurosurgery. Mov Disord.

Wilson CJ, Bevan MD (2011) Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neurons in health and in Parkinson’s disease. Neuroscience 198: 54-68. PMID: 21723918

Wilson, CJ, Beverlin, B II, and Netoff, T (2011) Chaotic desynchronization as the therapeutic mechanism of deep brain stimulation. Frontiers in Systems Neuroscience. 5:50.

Wilson, CJ and Bevan, MD (2011) Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neuron in health and in Parkinson’s disease. Neuroscience 198:54-68.

2010

Chang, C.C., Cao, S., Kang, S., Kai, L., Tian, X., Pandey, P., Dunne, S.F., Luan, C.H., Surmeier, D.J., and Silverman, R.B. (2010). Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2. Bioorg Med Chem 18, 3147-3158.

Dodla, R. and Wilson, C.J. (2010) Quantification of clustering in joint interspike interval scattergrams of spike trains. Biophys. J. 98:2535-2543.

Dodla, R. and Wilson, C.J. (2010) Coherence resonance due to transient thresholds in excitable systems. Phys. Rev. E 82:021105.

Farries, M.A., Kita, H. and Wilson, C.J. (2010) Dynamic spike threshold and zero membrane slope conductance shape the response of subthalamic neurons to cortical input. J. Neurosci. 30:13180-13191.

Guzman, J.N., Sanchez-Padilla, J., Wokosin, D., Kondapalli, J., Ilijic, E., Schumacker, P.T., and Surmeier, D.J. (2010). Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature 468, 696-700.

Simuni, T., Borushko, E., Avram, M.J., Miskevics, S., Martel, A., Zadikoff, C., Videnovic, A., Weaver, F.M., Williams, K., and Surmeier, D.J. (2010). Tolerability of isradipine in early Parkinson’s disease: a pilot dose escalation study. Mov Disord 25, 2863-2866.

Surmeier, D.J., Guzman, J.N., and Sanchez-Padilla, J. (2010). Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease. Cell Calcium47(2), 175-82.

Surmeier, D.J., Guzman, J.N., Sanchez-Padilla, J., and Goldberg, J.A. (2010). The Origins of Oxidant Stress in Parkinson’s Disease and Therapeutic Strategies. Antioxid Redox Signal.

Surmeier, D.J., Guzman, J.N., Sanchez-Padilla, J., and Goldberg, J.A. (2010). What causes the death of dopaminergic neurons in Parkinson’s disease? Prog Brain Res 183, 59-77.

Kita, H. The globus pallidus. In H. Steiner and K.y. Tseng (Eds.), Handbook of the Basal Ganglia Structure and Function, Elsevier, 2010, pp 233-247.

Farries MA, Kita H, Wilson CJ (2010) Dynamic spike threshold and zero membrane slope conductance shape the response of subthalamic neurons to cortical input. J Neurosci 30:13180-13191.

Atherton JF, Kitano K, Baufreton J, Fan K, Wokosin D, Tkatch T, Shigemoto R, Surmeier DJ, Bevan MD (2010) Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus. J Neurosci 30: 16025-16040. PMID: 21106841

Dodla, R and Wilson, CJ (2010) A phase function to quantify serial dependence between discrete samples. Biophys. J. 98:L5-7.

Dodla, R and Wilson, CJ (2010) Quantification of clustering in joint interspike interval scattergrams of spike trains.  Biophys. J. 98:2535-2543.

Dodla, R and Wilson, CJ (2010) Coherence resonance due to transient thresholds in excitable systems.  Phys. Rev. E 82:021105.

Farries, MA, Kita, H and Wilson, C. (2010) Dynamic spike threshold and zero membrane slope conductance shape the response of subthalamic neurons to cortical input.  J. Neurosci. 30:13180-13191.

2009

Watanabe K, Kita T, Kita H (2009) Presynaptic actions of d2-like receptors in the rat cortico-striato-globus pallidus disynaptic connection in vitro. J Neurophysiol 101:665-671.

Barraza D, Kita H, Wilson CJ (2009) Slow spike frequency adaptation in neurons of the rat subthalamic nucleus. J Neurophysiol 102:3689-3697.

Baufreton J, Kirkham E, Atherton JF, Menard A, Magill PJ, Bolam JP, Bevan MD (2009) Sparse but selective and potent synaptic transmission from the globus pallidus to the subthalamic nucleus. J Neurophysiol 102: 532-545. PMID: 19458148

Blythe SN, Wokosin D, Atherton JF, Bevan MD (2009) Cellular mechanisms underlying burst firing in substantia nigra dopamine neurons. J Neurosci 29: 15531-41. PMID: 20007477

Barraza, D, Kita, H, and Wilson, CJ (2009) Slow spike frequency adaptation in neurons of the rat subthalamic nucleus. J. Neurophysiol. 102:3689- 3697.

Deister, CA, Chan, CS, Surmeier, DJ, and Wilson, CJ (2009) Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons. J. Neurosci. 29:8452-8461.

Deister, CA, Teagarden, MA, Wilson, CJ and Paladini, CA (2009) An intrinsic neuronal oscillator underlies dopaminergic neuron bursting. J. Neurosci. 29:15888-15897.

Dodla R and Wilson, CJ Asynchronous response of coupled pacemaker neurons.  Phys. Rev. Lett. 2009 102(6):068102

2008

Tachibana Y, Kita H, Chiken S, Takada M, Nambu A (2008) Motor cortical control of internal pallidal activity through glutamatergic and GABAergic inputs in awake monkeys. Eur J Neurosci 27:238-253.

Hashimoto K, Kita H (2008) Serotonin activates presynaptic and postsynaptic receptors in rat globus pallidus. J Neurophysiol 99:1723-1732.

Atherton JF, Wokosin DL, Ramanathan S, Bevan MD (2008) Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus. J Physiol 586: 5679-5700. PMID: 18832425

Teagarden M, Atherton JF, Bevan MD Wilson CJ Accumulation of cytoplasmic calcium, but not apamin-sensitive afterhyperpolarization current, during high frequency firing in rat subthalamic nucleus cells. J. Physiol. 2008, 586:817-833.

Ramanathan S, Tkatch T, Atherton JF, Wilson CJ, Bevan MD D2-like dopamine receptors modulate SKCa channel function in subthalamic nucleus neurons through inhibition of Cav2.2 channels. J. Neurophysiol. 2008 99:442-459.

2007

Kita H, Chiken S, Tachibana Y, Nambu A (2007) Serotonin modulates pallidal neuronal activity in the awake monkey. J Neurosci 27:75-83. 

Kita H (2007) Globus pallidus external segment. Prog Brain Res 160:111-133.

Kaneda K, Kita T, Kita H (2007) Repetitive activation of glutamatergic inputs evokes a long-lasting excitation in rat globus pallidus neurons in vitro. J Neurophysiol 97:121-133.

Goldberg JA, Deister CA and WIlson CJ (2007) Response properties and synchronization of rhythmically firing dendritic neurons.  J. Neurophysiol. 97:208-219.

Best J, Park C Terman D and Wilson C (2007) Transitions between irregular and rhythmic firing patterns in excitatory-inhibitory neuronal networks.  J. Computational Neurosci. 23:217-235.