Northwestern University Feinberg School of Medicine

Department of Physiology

Publications

2017

Surmeier DJ, Obeso JA, Halliday GM. Parkinson's Disease Is Not Simply a Prion Disorder. J Neurosci. 2017 Oct 11;37(41):9799-9807. doi: 10.1523/JNEUROSCI.1787-16.2017. Review. PMID: 29021297.

Galtieri DJ, Estep CM, Wokosin DL, Traynelis S, Surmeier DJ. Pedunculopontine glutamatergic neurons control spike patterning in substantia nigra dopaminergic neurons. Elife. 2017 Oct 5;6. pii: e30352. doi: 10.7554/eLife.30352. PMID: 28980939.

Chu HY, McIver EL, Kovaleski RF, Atherton JF, Bevan MD. Loss of Hyperdirect Pathway Cortico-Subthalamic Inputs Following Degeneration of Midbrain Dopamine Neurons. Neuron. 2017 Sep 13;95(6):1306-1318.e5. doi: 10.1016/j.neuron.2017.08.038. PMID: 28910619.

Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, Krainc D. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science. 2017 Sep 22;357(6357):1255-1261. doi: 10.1126/science.aam9080. Epub 2017 Sep 7. PMID: 28882997.

Higgs MH, Wilson CJ. Measurement of phase resetting curves using optogenetic barrage stimuli. J Neurosci Methods. 2017 Sep 1;289:23-30. doi: 10.1016/j.jneumeth.2017.06.018. Epub 2017 Jun 28. PMID: 28668267.

Dodla R, Wilson CJ. Effect of Phase Response Curve Shape and Synaptic Driving Force on Synchronization of Coupled Neuronal Oscillators. Neural Comput. 2017 Jul;29(7):1769-1814. doi: 10.1162/NECO_a_00978. Epub 2017 May 31. PMID:28562223.

Shi H, Deng HX, Gius D, Schumacker PT, Surmeier DJ, Ma YC. Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress. Hum Mol Genet. 2017 May 15;26(10):1915-1926. doi: 10.1093/hmg/ddx100. PubMed PMID: 28369333.

Abrahao KP, Chancey JH, Chan CS, Lovinger DM. Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus. Neuropsychopharmacology. 2017 Apr;42(5):1070-1081. doi: 10.1038/npp.2016.251. Epub 2016 Nov 9. PubMed PMID: 27827370; PubMed Central PMCID: PMC5506786.

Surmeier DJ, Schumacker PT, Guzman JD, Ilijic E, Yang B, Zampese E. Calcium and Parkinson's disease. Biochem Biophys Res Commun. 2017 Feb 19;483(4):1013-1019. doi: 10.1016/j.bbrc.2016.08.168. Epub 2016 Aug 30. Review. PubMed PMID: 27590583; PubMed Central PMCID: PMC5449761.

Surmeier DJ, Obeso JA, Halliday GM. Selective neuronal vulnerability in Parkinson disease. Nat Rev Neurosci. 2017 Jan 20;18(2):101-113. doi: 10.1038/nrn.2016.178. Review. PubMed PMID: 28104909.

2016

Estep CM, Galtieri DJ, Zampese E, Goldberg JA, Brichta L, Greengard P, Surmeier DJ. Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons. PLoS One. 2016 Dec 30;11(12):e0169044. doi: 10.1371/journal.pone.0169044. eCollection 2016. PubMed PMID: 28036359; PubMed Central PMCID: PMC5201262.

Atherton JF, McIver EL, Mullen MR, Wokosin DL, Surmeier DJ, Bevan MD. Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease. Elife. 2016 Dec 20;5. pii: e21616. doi: 10.7554/eLife.21616. PubMed PMID: 27995895; PubMed Central PMCID: PMC5199195.

Cui Q, Pitt JE, Pamukcu A, Poulin JF, Mabrouk OS, Fiske MP, Fan IB, Augustine EC, Young KA, Kennedy RT, Awatramani R, Chan CS. Blunted mGluR Activation Disinhibits Striatopallidal Transmission in Parkinsonian Mice. Cell Rep. 2016 Nov 22;17(9):2431-2444. doi: 10.1016/j.celrep.2016.10.087. PubMed PMID: 27880915; PubMed Central PMCID: PMC5489133.

Song SC, Beatty JA, Wilson CJ. The ionic mechanism of membrane potential oscillations and membrane resonance in striatal LTS interneurons. J Neurophysiol. 2016 Oct 1;116(4):1752-1764. doi: 10.1152/jn.00511.2016. Epub 2016 Jul 20. PubMed PMID: 27440246; PubMed Central PMCID: PMC5144687.

Higgs MH, Wilson CJ. Unitary synaptic connections among substantia nigra pars reticulata neurons. J Neurophysiol. 2016 Jun 1;115(6):2814-29. doi: 10.1152/jn.00094.2016. Epub 2016 Mar 9. PubMed PMID: 26961101; PubMed Central PMCID: PMC4946591.

Glajch KE, Kelver DA, Hegeman DJ, Cui Q, Xenias HS, Augustine EC, Hernández VM, Verma N, Huang TY, Luo M, Justice NJ, Chan CS. Npas1+ Pallidal Neurons Target Striatal Projection Neurons. J Neurosci. 2016 May 18;36(20):5472-88. doi: 10.1523/JNEUROSCI.1720-15.2016. PubMed PMID: 27194328; PubMed Central PMCID: PMC4871984.

Hegeman DJ, Hong ES, Hernández VM, Chan CS. The external globus pallidus: progress and perspectives. Eur J Neurosci. 2016 May;43(10):1239-65. doi: 10.1111/ejn.13196. Epub 2016 Mar 28. Review. PubMed PMID: 26841063; PubMed Central PMCID: PMC4874844.

2015

Cooper G, Lasser-Katz E, Simchovitz A, Sharon R, Soreq H, Surmeier DJ, Goldberg JA. Functional segregation of voltage-activated calcium channels in motoneurons of the dorsal motor nucleus of the vagus. J Neurophysiol. 2015 Sep;114(3):1513-20. doi: 10.1152/jn.00432.2014. Epub 2015 Jul 8. PubMed PMID: 26156385; PubMed Central PMCID: PMC4561632.

Hernández VM, Hegeman DJ, Cui Q, Kelver DA, Fiske MP, Glajch KE, Pitt JE, Huang TY, Justice NJ, Chan CS. Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus. J Neurosci. 2015 Aug 26;35(34):11830-47. doi: 10.1523/JNEUROSCI.4672-14.2015. PubMed PMID: 26311767; PubMed Central PMCID: PMC4549397.

Chu HY, Atherton JF, Wokosin D, Surmeier DJ, Bevan MD. Heterosynaptic regulation of external globus pallidus inputs to the subthalamic nucleus by the motor cortex. Neuron. 2015 Jan 21;85(2):364-76. doi: 10.1016/j.neuron.2014.12.022. Epub 2015 Jan 8. PubMed PMID: 25578364; PubMed Central PMCID: PMC4304914.

2014

Wilson CJ. Oscillators and Oscillations in the Basal Ganglia. Neuroscientist. 2014 Dec 1. pii: 1073858414560826. [Epub ahead of print] Review. PubMed PMID: 25449134; PubMed Central PMCID: PMC4454624.

Surmeier DJ, Graves SM, Shen W. Dopaminergic modulation of striatal networks in health and Parkinson's disease. Curr Opin Neurobiol. 2014 Dec;29:109-17. doi: 10.1016/j.conb.2014.07.008. Epub 2014 Jul 22. Review. PubMed PMID: 25058111; PubMed Central PMCID: PMC4418190.

Sanchez-Padilla J, Guzman JN, Ilijic E, Kondapalli J, Galtieri DJ, Yang B, Schieber S, Oertel W, Wokosin D, Schumacker PT, Surmeier DJ. Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. Nat Neurosci. 2014 Jun;17(6):832-40. doi: 10.1038/nn.3717. Epub 2014 May 11. PubMed PMID: 24816140; PubMed Central PMCID: PMC4131291.

Wilson CJ, Barraza D, Troyer T, Farries MA. Predicting the responses of repetitively firing neurons to current noise. PLoS Comput Biol. 2014 May 8;10(5):e1003612. doi: 10.1371/journal.pcbi.1003612. eCollection 2014 May. PubMed PMID: 24809636; PubMed Central PMCID: PMC4014400.

2012

Goldberg JA, Guzman JN, Estep CM, Ilijic E, Kondapalli J, Sanchez-Padilla J, Surmeier DJ. Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease. Nat Neurosci. 2012 Oct;15(10):1414-21. doi: 10.1038/nn.3209. Epub 2012 Sep 2. PubMed PMID: 22941107; PubMed Central PMCID: PMC3461271.

Glajch KE, Fleming SM, Surmeier DJ, Osten P. Sensorimotor assessment of the unilateral 6-hydroxydopamine mouse model of Parkinson's disease. Behav Brain Res. 2012 May 1;230(2):309-16. doi: 10.1016/j.bbr.2011.12.007. Epub 2011 Dec 9. PubMed PMID: 22178078; PubMed Central PMCID: PMC3324279.

2011

Wilson CJ, Bevan MD. Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neurons in health and in Parkinson's disease. Neuroscience. 2011 Dec 15;198:54-68. doi: 10.1016/j.neuroscience.2011.06.049. Epub 2011 Jun 22. PubMed PMID: 21723918; PubMed Central PMCID: PMC3206160.

Surmeier DJ, Guzman JN, Sanchez-Padilla J, Schumacker PT. The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's diseaseNeuroscience. 2011 Dec 15;198:221-31. doi: 10.1016/j.neuroscience.2011.08.045. Epub 2011 Aug 25. Review. PubMed PMID: 21884755; PubMed Central PMCID: PMC3244353.

2010

Kita T, Kita H. Cholinergic and non-cholinergic mesopontine tegmental neurons projecting to the subthalamic nucleus in the rat. Eur J Neurosci. 2011 Feb;33(3):433-43. doi: 10.1111/j.1460-9568.2010.07537.x. Epub 2010 Dec 31. PubMed PMID: 21198985; PubMed Central PMCID: PMC3075811.

Atherton JF, Kitano K, Baufreton J, Fan K, Wokosin D, Tkatch T, Shigemoto R, Surmeier DJ, Bevan MD. Selective participation of somatodendritic HCN channels in inhibitory but not excitatory synaptic integration in neurons of the subthalamic nucleus. J Neurosci. 2010 Nov 24;30(47):16025-40. doi: 10.1523/JNEUROSCI.3898-10.2010. PubMed PMID: 21106841; PubMed Central PMCID: PMC3073577.

Guzman JN, Sanchez-Padilla J, Wokosin D, Kondapalli J, Ilijic E, Schumacker PT, Surmeier DJ. Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature. 2010 Dec 2;468(7324):696-700. doi: 10.1038/nature09536. Epub 2010 Nov 10. Erratum in: Nature. 2015 May 21;521(7552):380. PubMed PMID: 21068725; PubMed Central PMCID: PMC4465557.

Surmeier DJ, Guzman JN, Sanchez-Padilla J. Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease. Cell Calcium. 2010 Feb;47(2):175-82. doi: 10.1016/j.ceca.2009.12.003. Epub 2010 Jan 6. Review. PubMed PMID: 20053445; PubMed Central PMCID: PMC3235732.

2009

Guzman JN, Sánchez-Padilla J, Chan CS, Surmeier DJ. Robust pacemaking in substantia nigra dopaminergic neurons. J Neurosci. 2009 Sep 2;29(35):11011-9. doi: 10.1523/JNEUROSCI.2519-09.2009. PubMed PMID: 19726659; PubMed Central PMCID: PMC2784968.

Deister CA, Chan CS, Surmeier DJ, Wilson CJ. Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons. J Neurosci. 2009 Jul 1;29(26):8452-61. doi: 10.1523/JNEUROSCI.0576-09.2009. PubMed PMID: 19571136; PubMed Central PMCID: PMC3329865.

Dodla R, Wilson CJ. Asynchronous response of coupled pacemaker neurons. Phys Rev Lett. 2009 Feb 13;102(6):068102. Epub 2009 Feb 10. PubMed PMID: 19257636; PubMed Central PMCID: PMC2679421.