Northwestern University Feinberg School of Medicine

Department of Physiology

Myongsoo Matthew Oh, PhD

Myongsoo Matthew Oh, PhD

Research Assistant Professor of Physiology

Focus of Work

Bio

I am interested in identifying why learning becomes progressively more difficult with normal aging. With this broad goal in mind, I am studying the cellular properties of principle neurons of the hippocampus as an animal ages and after an animal has learned a task that involve the hippocampus. Thus far, my colleagues and I have identified that hippocampal pyramidal neurons (the principle output neurons of the hippocampus) become more excitable (that is, they are able to fire more action potentia...[Read full text]I am interested in identifying why learning becomes progressively more difficult with normal aging. With this broad goal in mind, I am studying the cellular properties of principle neurons of the hippocampus as an animal ages and after an animal has learned a task that involve the hippocampus. Thus far, my colleagues and I have identified that hippocampal pyramidal neurons (the principle output neurons of the hippocampus) become more excitable (that is, they are able to fire more action potentials) following successful learning. More importantly, the same population of neurons become less excitable with normal aging. Thus, it is our working hypothesis that the reduced excitability levels of the hippocampal pyramidal neurons with normal aging is a cause of the learning deficits observed in the aging population. We are currently using state of the art calcium imaging techniques to further characterize the changes in the hippocampal pyramidal neurons following learning and with normal aging. By systematically examining these cellular changes that occur following successful learning and with normal aging, a goal is to identify potential pharmacological targets to ameliorate and/or reverse the normal aging-related cognitive deficits. In addition, given that incidence of Alzheimer's disease increases with age, it is another goal of our research to translate our findings and approach to identify the cellular changes that occur in this debilitating condition.[Shorten text]

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Education and Certification

  • PhD: Northwestern University, Neuroscience (2002)
  • Postdoctoral Fellowship: Northwestern University/Feinberg School of Medicine, Neuroscience (2008)

Contact

312-503-5123

Ward Building Room 5-654
303 E Chicago Avenue
Chicago IL 60611