Chicago - 12:00 PM - 1:00 PM
The department of Physiology welcomes Motoharu Yoshida, Ph.D., Group Leader, with the Leibniz Institute for Neurobiology (LIN) and German Center for Neurodegenerative Diseases (DZNE) Magdeburg, Germany
Persistent firing is believed to support temporal bridging tasks such as working memory and trace conditioning. Although recurrent synaptic excitation is widely believed to support persistent firing, recent studies have established that neurons can support persistent firing through an intrinsic cellular mechanisms. Here, I will demonstrate that individual hippocampal pyramidal cells support persistent firing through the transient receptor potential-canonical (TRPC) channels under cholinergic receptor activation. In contrast, this persistent firing is suppressed by noradrenaline (NA) and serotonin (5HT) through cAMP elevation, which is in line with impaired working memory in high NA and 5HT. In addition, mice with TRPC5 channel knockout were impaired in trace-fear conditioning, suggesting that TRPC channels supports temporal bridging function in vivo. Furthermore, computational simulations indicate that TRPC channels may support "time cell" activity observed in the hippocampus.